The following members of the Pro Football Hall of Fame earned player of the game honors in a Pro Bowl.
Gale Sayers - 1967, 1968, 1970
| 1951 - Otto Graham | 1969 (AFL) - Len Dawson (OOP) |
| 1954 - Chuck Bednarik | 1969 - Merlin Olsen (OL) |
| 1956 - Ollie Matson | 1970 - Gale Sayers (OB) |
| 1957 - Ernie Stautner (OL) | 1971 - Mel Renfro (OB) |
| 1958 - Hugh McElhenny (OB) | 1972 - Jan Stenerud (OOP), Willie Lanier (ODP) |
| 1959 - Frank Gifford (OB) Doug Atkins (OL) | 1973 - O.J. Simpson |
| 1960 - Johnny Unitas (OB) | 1977 - Mel Blount |
| 1961 - Johnny Unitas (OB), Sam Huff (OL) | 1978 - Walter Payton |
| 1962 - Jim Brown (OB), Henry Jordan (OL) | 1982 - Lee Roy Selmon* & Kellen Winslow* |
| 1963 - Jim Brown (OB) | 1983 - Dan Fouts* |
| 1964 - Johnny Unitas (OB), Gino Marchetti (OL) | 1987 - Reggie White |
| 1965 - Fran Tarkenton (OB) | 1988 - Bruce Smith |
| 1965 (AFL) - Willie Brown (ODP) | 1991 - Jim Kelly |
| 1966 (AFL) - Joe Namath (OOP) | 1992 - Michael Irvin |
| 1966 - Jim Brown (OB) | 1995 - Marshall Faulk |
| 1967 - Gale Sayers (OB) | 1996 - Jerry Rice |
| 1968 (AFL) - Joe Namath* (OOP) & Don Maynard* (OOP) | 1998 - Warren Moon |
| 1968 - Dave Robinson (OL), Gale Sayers (OB) | 2000 - Randy Moss |
| 2006 - Derrick Brooks | |
|
(OB) - Outstanding Back; (OL) - Outstanding Lineman; (ODP) - Outstanding Defensive Player; (OOP) Outstanding Offensive Player; * Shared honors |
|