Interceptions (at start of 2026 NFL Season)
| 1 | Paul Krause* | 81 |
| 2 | Emlen Tunnell* | 79 |
| 3 | Rod Woodson* | 71 |
| 4 | Dick "Night Train" Lane* | 68 |
| 5 | Ken Riley* | 65 |
| 5T | Charles Woodson* | 65 |
| 7 | Ed Reed* | 64 |
| 8 | Ronnie Lott* | 63 |
| 8T | Darren Sharper | 63 |
| 10 | Dave Brown | 62 |
| 10T | Dick LeBeau* | 62 |
| 12 | Emmitt Thomas* | 58 |
| 13 | Mel Blount* | 57 |
| 13T | Bobby Boyd | 57 |
| 13T | Eugene Robinson | 57 |
| 13T | Johnny Robinson | 57 |
| 13T | Everson Walls | 57 |
| 18 | Lem Barney* | 56 |
| 18T | Pat Fischer | 56 |
| 20 | Aeneas Williams | 55 |
|
* Pro Football Hall of Fame member |